HCID 58238625, compound → HCID 136177199, compound

Participants

Reaction Steps

Compound 10 (1.5 g, 3.3 mmol, 1.0 equiv) was dissolved in ethanol (50 mL) and 10% palladium (50% aqueous) on carbon (0.2 g) was added. The material was shaken on a Parr hydrogenator under a hydrogen atmosphere (30 psi) for 18 hr. The reaction was filtered through a bed of Celite and rinsed with dichloromethane (100 mL). The product was absorbed onto silica gel (4 g) by concentration under reduced pressure. This material was purified on a silica gel column (30 g) by eluting with heptanes (200 mL), ethyl acetate (2%) in heptanes (200 mL), ethyl acetate (3%) in heptanes (200 mL) and ethyl acetate (4%) in heptanes (100 mL). The desired product was isolated pure in 87% yield (1.0 g).

Provenance & Evidence