HCID 58238618, compound → HCID 136177200, compound

Participants

Reaction Steps

Compound 12 (0.8 g, 1.66 mmol, 1.0 equiv) was dissolved in ethanol (30 mL) and 10% palladium (50% aqueous) on carbon (0.2 g) was added. The material was shaken on a Parr hydrogenator under a hydrogen atmosphere (30 psi) for 4 hr. The reaction was filtered through a bed of Celite and rinsed with dichloromethane (100 mL). The product was absorbed onto silica gel (3 g) by concentration under reduced pressure. This material was purified on a silica gel column (20 g) by eluting with heptanes (250 mL) and ethyl acetate (1%) in heptanes (500 mL). The desired product was isolated pure in 77% yield (0.5 g).

Provenance & Evidence