HCID 58238626, compound → HCID 136177198, compound

Participants

Reaction Steps

Compound 13 (1.0 g, 2.38 mmol, 1.0 equiv) was dissolved in ethanol (30 mL) and 10% palladium (50% aqueous) on carbon (0.2 g) was added. The material was shaken on a Parr hydrogenator under a hydrogen atmosphere (30 psi) for 3 hr. The reaction was filtered through a bed of Celite and rinsed with dichloromethane (100 mL). The product was absorbed onto silica gel (5 g) by concentration under reduced pressure. This material was purified on a silica gel column (50 g) by eluting with ethyl acetate (0.5%) in heptanes (800 mL). The desired product was isolated pure in 36% yield (0.3 g).

Provenance & Evidence