Ethyl 2-[2-amino-4-(1,3-dihydroisoindole-2-carbonyl)-quinazolin-6-yl]benzoate → 2-[2-Amino-4-(1,3-dihydroisoindole-2-carbonyl)quinazolin-6-yl]benzoic acid

Participants

Reaction Steps

A solution of 15.3 g of ethyl 2-[2-amino-4-(1,3-dihydroisoindole-2-carbonyl)-quinazolin-6-yl]benzoate in 70 ml of sodium hydroxide solution (2 N) and 100 ml of THF is stirred at 80° C. for 6 h. The mixture is extracted three times with 100 ml of diethyl ether each time, and the aqueous phase is adjusted to pH7, whereupon 2-[2-amino-4-(1,3-dihydroisoindole-2-carbonyl)quinazolin-6-yl]benzoic acid precipitates out. The precipitate is filtered and dried at 50° C. in a drying cabinet.

Provenance & Evidence