2-Bromobenzenesulfonyl chloride → HCID 58457197, compound

HRID 1037687Notes

Reaction equation

HRID 1037687 reaction equation
[CH:1]1([NH:4][CH3:5])[CH2:3][CH2:2]1.[Br:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=1[S:13](Cl)(=[O:15])=[O:14]>C(Cl)Cl>[Br:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=1[S:13]([N:4]([CH:1]1[CH2:3][CH2:2]1)[CH3:5])(=[O:15])=[O:14]

Participants

4

Reactant 2

HCID 5204032-Bromobenzenesulfonyl chlorideHCID 11029756N-Methylcyclopropanamine

Product 1

HCID 58457197HCID 58457197, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Conditions

Temperature
22 °C

Procedure

450 μl of N-cyclopropyl-N-methylamine are added dropwise with cooling to a solution of 640 mg of 2-bromobenzenesulfonyl chloride in 2.5 ml of DCM. The mixture is subsequently stirred at 22° C. for 2 h, extracted twice with 5 ml of 1N sodium hydroxide solution, the organic phase is dried over magnesium sulfate, filtered and evaporated in vacuo.

Workup

  1. extractionextracted twice with 5 ml of 1N sodium hydroxide solution
  2. dry with materialthe organic phase is dried over magnesium sulfate
  3. filtrationfiltered
  4. customevaporated in vacuo

Sources & evidence

ORD record
ord-8c362dd4c27b45b580d1b53893c3add8
Source dataset
uspto-grants-2013_10
Patent number
US08546565B2

Reaction notes

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