HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1037689Generated: October 31, 2026
Water → 2-[2-amino-4-(1,3-dihydroisoindole-2-carbonyl)quinazolin-6-yl]-N-tert-butylbenzenesulfonamide
https://huagongshe.com/reaction/1037689
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Boronic acid, B-(2-(((1,1-dimethylethyl)amino)sulfonyl)phenyl)- | HCID 4997616 | — |
| Reactant | (2-Amino-6-iodoquinazolin-4-yl)isoindolin-2-ylmethanone | HCID 58457195 | — |
| Catalyst | Bis(cyclopenta-1,4-dien-1-yl(diphenyl)phosphane);dichloropalladium;iron(2+) | HCID 178418228 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 2-[2-amino-4-(1,3-dihydroisoindole-2-carbonyl)quinazolin-6-yl]-N-tert-butylbenzenesulfonamide | HCID 46701754 | — |
Reaction Steps
1.6 g of 2-borono-N-tert-butylbenzenesulfonamide, 2.66 g of potassium carbonate, 86 μl of water and 196 mg of [1,1′-bis(diphenylphosphino)ferrocene]palladium(II)dichloride are added to a solution of 2 g of 2-amino-6-iodo-4-(1,3-dihydroisoindol-2-ylcarbonyl)quinazoline in 100 ml of ethanol under argon. The mixture is heated at 120° C. for 16 h, giving a clear solution. The hot solution is filtered through kieselguhr and rinsed with ethanol. The filtrate is evaporated to dryness in vacuo. Crystallisation of the residue from 5 ml of acetonitrile/water gives the product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08546565B2 |
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| Source dataset | uspto-grants-2013_10 |
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| ORD ID | ord-d1667a50c2b64b6fbc17ec0123adfd3f |
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| Source note | uspto-grants-2013_10 |
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