Dicyclohexylcarbodiimide → HCID 67434865, compound

Participants

Reaction Steps

56 mg of tert-butoxycarbonylaminoacetic acid, 33 mg of N,N′-dicyclohexylcarbodiimide and 2 mg of dimethylaminopyridine (DMAP) are added to a solution of 80 mg of 2-[2-amino-4-(1,3-dihydroisoindole-2-carbonyl)quinazolin-6-yl]-N-(2-hydroxyethyl)-N-methylbenzenesulfonamide in 1 ml of THF. After 120 min, the mixture is evaporated in vacuo, the residue is taken up in 1 ml of DCM:TFA (1:1) with cooling, and the mixture is stirred for 30 min. The mixture is evaporated to dryness in vacuo, the residue is taken up in 500 μl of DMSO and purified by column chromatography on a reversed phase.

Provenance & Evidence