Hydrochloric Acid → HCID 57734091, compound

Participants

Reaction Steps

A solution of 40 mg of ester 16 (0.09 mmol) in 0.72 mL of THF was hydrolyzed with 360 uL of aqueous lithium hydroxide (0.5M, 0.18 mmol)) at 23° C. for 16 h. The mixture was acidified by addition of 1N HCl and then extracted with EtOAc (2×). The combined organic portions were washed with brine (2×), dried over anhydrous Na2SO4, filtered and concentrated in vacuo to yield 23.3 mg (60%) of the free acid 17.

Provenance & Evidence