HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → 2-(2-Dimethylamino-ethyl)-5-nitro-2H-isoquinolin-1-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | N,N-Dimethylethylenediamine | HCID 66053 | — |
| Reactant | 5-nitro-1H-isochromen-1-one | HCID 10012760 | — |
| Product | 2-(2-Dimethylamino-ethyl)-5-nitro-2H-isoquinolin-1-one | HCID 59579267 | — |
Reaction Steps
5-Nitro-isochromen-1-one (1.83 g, 0.00957 mol) and N,N-dimethyl-1,2-ethanediamine (3 g, 0.03 mol) were refluxed in methanol (20 mL, 0.5 mol) for 1 hour. The volatiles were removed via rotovapor. The residue was purified via flash chromatography (40 g of silica gel, 50% EtOAc/CH2Cl2) and gave a light yellow solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08546579B2 |
| Source dataset | uspto-grants-2013_10 |
| ORD ID | ord-d87f8241621344a084dc7e07d8405513 |
| Source note | uspto-grants-2013_10 |