2-(2-Dimethylamino-ethyl)-5-nitro-2H-isoquinolin-1-one → 5-Amino-2-(2-dimethylamino-ethyl)-2H-isoquinolin-1-one

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Reaction Steps

2-(2-Dimethylamino-ethyl)-5-nitro-2H-isoquinolin-1-one (1.10 g, 0.00358 mol) was dissolved in MeOH (30 mL), Pd/C (10%) was added and the mixture was stirred under an atmosphere of hydrogen at room temperature for 1 h. The mixture was filtered through Celite, and the solvent was removed in vacuo to give the titled product as a light yellow solid (0.82 g). MS m/z (M+H) 232.4.

Provenance & Evidence