HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → 2-(2,3-Dihydro-benzo[1,4]dioxin-6-ylmethyl)-5-nitro-2H-isoquinolin-1-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | 2,3-Dihydro-1,4-benzodioxin-6-methylamine | HCID 87102 | — |
| Reactant | 5-nitro-1H-isochromen-1-one | HCID 10012760 | — |
| Product | 2-(2,3-Dihydro-benzo[1,4]dioxin-6-ylmethyl)-5-nitro-2H-isoquinolin-1-one | HCID 58270406 | — |
Reaction Steps
5-Nitro-isochromen-1-one (1.0 g, 0.0052 mol) and C-(2,3-dihydro-benzo[1,4]dioxin-6-yl)-methylamine (1.0 g, 0.0060 mol) were refluxed in methanol (40 mL, 1 mol) for 2 hours. The solvent was removed and the residue was purified via flash chromatography (40 g of silica gel, 0-30% EtOAc/Hexanes) to give a yellow solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08546579B2 |
| Source dataset | uspto-grants-2013_10 |
| ORD ID | ord-febc8475020b4f30b5d3896c996452d4 |
| Source note | uspto-grants-2013_10 |