HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tetrahydrofuran → 5-Amino-2-methyl-1(2H)-isoquinolinone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Reactant | Stannous chloride dihydrate | HCID 61436 | — |
| Reactant | 2-Methyl-5-nitro-2H-isoquinolin-1-one | HCID 311856 | — |
| Product | 5-Amino-2-methyl-1(2H)-isoquinolinone | HCID 12220344 | — |
Reaction Steps
2-Methyl-5-nitro-2H-isoquinolin-1-one (0.69 g, 0.0032 mol) and tin dichloride dihydrate (2 g, 0.01 mol) were stirred in tetrahydrofuran (10 mL, 0.1 mol) at room temperature overnight. The mixture was purified via flash chromatography (40 g of silica gel, 50% EtOAc/Hexanes) to give a brown solid. MS m/z (M+H) 174.9.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08546579B2 |
| Source dataset | uspto-grants-2013_10 |
| ORD ID | ord-1c7aaa3657c348daa9a1bd6a19ae6e99 |
| Source note | uspto-grants-2013_10 |