HCID 59515706, compound → HCID 59515675, compound

HRID 1037775Notes

Reaction equation

HRID 1037775 reaction equation
[C:1]([O:4][CH2:5][CH2:6][N:7]1[CH:16]=[CH:15][C:14]2[C:9](=[CH:10][CH:11]=[CH:12][C:13]=2[N+:17]([O-])=O)[C:8]1=[O:20])(=[O:3])[CH3:2]>CO.[Pd]>[C:1]([O:4][CH2:5][CH2:6][N:7]1[CH:16]=[CH:15][C:14]2[C:9](=[CH:10][CH:11]=[CH:12][C:13]=2[NH2:17])[C:8]1=[O:20])(=[O:3])[CH3:2]

Participants

4

Reactant 1

HCID 59515706HCID 59515706, compound

Product 1

HCID 59515675HCID 59515675, compoundYield 95.5%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A mixture of 2-(5-Nitro-1-oxoisoquinolin-2(1H)-yl)ethyl acetate (2.45 g, 0.00842 mol) was dissolved in methanol (100 mL), palladium on charcoal (10%) was stirred under an atmosphere of hydrogen for 1 hour. The mixture was filtered through celite, solvent was removed to obtain the product as a light orange solid (1.98 g). MS m/z=248.0 (M+H).

Workup

  1. filtrationThe mixture was filtered through celite, solvent
  2. customwas removed

Sources & evidence

ORD record
ord-ddf17c049a5749b0a9509b9ac2ecf500
Source dataset
uspto-grants-2013_10
Patent number
US08546579B2

Reaction notes

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