反应详情

温度

60 °C

C-(6-Trifluoromethyl-pyridin-3-yl)-methylamine (1.00 g, 0.00568 mol) and 5-nitro-isochromen-1-one (1.14 g, 0.00568 mol) were suspended in methanol (10 mL) and the suspension was stirred at 60° C. for 3 hours, then the reaction was microwaved at 100 watts at 100° C. for 60 minutes, and then at 120° C. for 30 min. Solid thus formed was filtered out to yield the product as a yellow solid (1.2 g). MS m/z=350.4 (M+H).

1. customthe reaction was microwaved at 100 watts at 100° C. for 60 minutes
2. waitat 120° C. for 30 min
3. customSolid thus formed
4. filtrationwas filtered out