反应详情

Palladium on charcoal (10%) was added to the solution of 2-((6-(trifluoromethyl)pyridin-3-yl)methyl)-5-nitroisoquinolin-1(2H)-one (1.16 g, 0.00315 mol) in methanol (30 mL) and the mixture was stirred under an atmosphere of hydrogen for 40 min. The mixture was filtered through celite. The filterate was concentrated and the residue was purified by column to obtain the product as a beige solid (0.83 g). MS m/z=320.3 (M+H).

1. filtrationThe mixture was filtered through celite
2. concentrationThe filterate was concentrated
3. customthe residue was purified by column