HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Hydroxybenzotriazole → 2,2,3,3-Tetramethylcyclopropanecarboxylic acid (4-methyl-5-morpholin-4-yl-thiazol-2-yl)-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Hydroxybenzotriazole | HCID 75771 | — |
| Reactant | 2,2,3,3-Tetramethylcyclopropanecarboxylic acid | HCID 152115 | — |
| Reactant | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| Reactant | 4-Methyl-5-morpholin-4-yl-thiazol-2-ylamine | HCID 86618905 | — |
| Solvent | Triethylamine | HCID 8471 | — |
| Product | 2,2,3,3-Tetramethylcyclopropanecarboxylic acid (4-methyl-5-morpholin-4-yl-thiazol-2-yl)-amide | HCID 86618904 | — |
Reaction Steps
A mixture of 4-methyl-5-morpholin-4-yl-thiazol-2-ylamine (prepared using the method described in Christopher et al., Bioorganic and Medicinal Chemistry Letters 2004, 14(22), 5521-5525), N-(3-dimethylaminopropyl)-N-ethylcarbodiimide hydrochloride, 1-hydroxybenzotriazole, triethylamine, and 2,2,3,3-tetramethylcyclopropanecarboxylic acid were processed using the method described in Example 58 to afford the title compound. MS (ESI+) m/z 324 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08546583B2 |
| Source dataset | uspto-grants-2013_10 |
| ORD ID | ord-e92aa6c16cc14cc4b2d433416ed30b27 |
| Source note | uspto-grants-2013_10 |