HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1037886Generated: October 26, 2026
Furan, 2-(bromomethyl)tetrahydro- → Ammonium Hydroxide
https://huagongshe.com/reaction/1037886
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Furan, 2-(bromomethyl)tetrahydro- | HCID 14501 | — |
| Reactant | 2-Amino-5-methylthiazole | HCID 351770 | — |
| Product | Ammonium Hydroxide | HCID 14923 | — |
| Product | 5-methyl-3-((tetrahydrofuran-2-yl)methyl)thiazol-2(3H)-imine | HCID 66851698 | — |
Reaction Steps
A mixture of 2-amino-5-methylthiazole (1 g, 8.7 mmol) and 2-(bromomethyl)tetrahydrofuran (1.1 mL, 10 mmol) was warmed to 85° C. and was allowed to stir for 24 hours. The mixture was cooled to ambient temperature and purified via flash column chromatography (SiO2, 10% methanol in ethyl acetate then 9:1:0.1 CH2Cl2:methanol:NH4OH) to afford the title compound. MS (DCI/NH3) m/z 199 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08546583B2 |
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| Source dataset | uspto-grants-2013_10 |
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| ORD ID | ord-a4402122b476444e863ffce2b9526339 |
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| Source note | uspto-grants-2013_10 |
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