Allyl bromide → 3-allyl-4,5-dimethylthiazol-2(3H)-imine hydrobromide

HRID 1037910Notes

Reaction equation

HRID 1037910 reaction equation
[CH3:1][C:2]1[N:3]=[C:4]([NH2:8])[S:5][C:6]=1[CH3:7].[CH2:9]([Br:12])[CH:10]=[CH2:11]>C1(C)C=CC=CC=1.CCOCC>[BrH:12].[CH2:11]([N:3]1[C:2]([CH3:1])=[C:6]([CH3:7])[S:5][C:4]1=[NH:8])[CH:10]=[CH2:9]

Participants

5

Reactant 2

HCID 7841Allyl bromideHCID 732382-Amino-4,5-dimethyl-1,3-thiazole

Product 1

HCID 686235423-allyl-4,5-dimethylthiazol-2(3H)-imine hydrobromide

Reagents, catalysts & solvents 2

HCID 1140TolueneSolventHCID 3283Diethyl EtherSolvent

Conditions

Temperature
85 °C

Procedure

A mixture of 4,5-dimethyl-1,3-thiazol-2-amine (1 g) and allylbromide (0.95 g) in toluene (5 mL) was heated to 85° C. for 12 hours, cooled, diluted with ether, filtered and the solvent was evaporated to afford crude product that was taken on to the next step without further characterization.

Workup

  1. temperaturecooled
  2. filtrationfiltered
  3. customthe solvent was evaporated
  4. customto afford crude product that

Sources & evidence

ORD record
ord-786ab40aa7b74ba1872f6be265767bde
Source dataset
uspto-grants-2013_10
Patent number
US08546583B2

Reaction notes

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