Hydrochloric Acid → HCID 68621578, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of pentane-2,4-dione (451 mg, 4.5 mmol) and the product from Example 278A (786 mg, 4.5 mmol) in tetrahydrofuran (5 mL) was added a mixture of dimethylsulfoxide (0.64 mL, 9.0 mmol) and concentrated HCl (0.75 mL, 9.0 mmol). The reaction mixture was heated at 40° C. for 12 hours. After cooling to ambient temperature, the mixture was diluted with ethyl acetate and washed with saturated aqueous NaHCO3. The organic extract was dried (Na2SO4), filtered and concentrated to afford the title compound. MS (ESI) m/z 241 (M+H)+.

Provenance & Evidence