HCID 178514971, compound → HCID 178507361, compound

HRID 1037996Notes

Reaction equation

HRID 1037996 reaction equation
[N+:1]([C:4]1[CH:5]=[C:6]2[C:10](=[CH:11][CH:12]=1)[NH:9][N:8]=[C:7]2[CH2:13][N:14]1[C:22](=[O:23])[C:21]2[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=2)[C:15]1=[O:24])([O-])=O>CO.[Pd]>[NH2:1][C:4]1[CH:5]=[C:6]2[C:10](=[CH:11][CH:12]=1)[NH:9][N:8]=[C:7]2[CH2:13][N:14]1[C:15](=[O:24])[C:16]2[C:21](=[CH:20][CH:19]=[CH:18][CH:17]=2)[C:22]1=[O:23]

Participants

4

Reactant 1

HCID 178514971HCID 178514971, compound

Product 1

HCID 178507361HCID 178507361, compoundYield 95.3%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

2-(5-Nitro-1H-indazol-3-ylmethyl)-isoindole-1,3-dione (0.71 gm) was dissolved in methanol and hydrogenated at 1 atm. using 10% Pd/C (catalytic) for 18 hrs. The catalyst was filtered and the mixture evaporated to obtain 614 mg of title product.

Workup

  1. customfor 18 hrs
  2. filtrationThe catalyst was filtered
  3. customthe mixture evaporated

Sources & evidence

ORD record
ord-7242e2225b794fcb9ab3cff0c11a1ab9
Source dataset
uspto-grants-2013_10
Patent number
US08546404B2

Reaction notes

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