反应详情

10 g of the crude acetate/alcohol mixture from Example 29 were taken up in approx. 90 ml of methanol and approx. 70 ml of water and washed three times with in each case approx. 50 ml of n-heptane. The combined heptane phases (contain predominantly the acetate) are extracted with 50 ml of 1:1 methanol/water. The combined aqueous phases are washed again with n-heptane. After concentrating the aqueous phase, 3.6 g of the desired (1S,3R)-3-benzyloxycyclohexan-1-ol were obtained, and the concentration of the combined heptane phases gave 5.5 g of the (1R,3S)-acetate.

1. washapprox. 70 ml of water and washed three times with in each case approx. 50 ml of n-heptane
2. extractionare extracted with 50 ml of 1:1 methanol/water
3. washThe combined aqueous phases are washed again with n-heptane
4. concentrationAfter concentrating the aqueous phase