関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Cesium fluoride | HCID 25953 | — |
| 反応物 | 2-(Tributylstannyl)pyrimidine | HCID 2763251 | — |
| 反応物 | Tert-butyl 4-(5-bromo-1,3-thiazol-2-yl)piperazine-1-carboxylate | HCID 34180719 | — |
| 触媒 | Di-t-butylphosphine palladium | HCID 86614436 | — |
| 生成物 | 4-(5-Pyrimidin-2-yl-thiazol-2-yl)-piperazine-1-carboxylic acid tert-butyl ester | HCID 59511356 | — |
反応手順
A round bottom flask containing 4-(5-bromo-thiazol-2-yl)-piperazine-1-carboxylic acid tert-butyl ester (100 mg, 0.29 mmol), 2-tributylstannanyl-pyrimidine (130 mg, 0.36 mmol), cesium fluoride (85 mg, 0.56 mmol) and palladium di-tert-butylphosphine was degassed three times with Ar. Dioxane was added and the formed reaction mixture was stirred at 90° C. overnight under Ar. Then the reaction mixture was filter through celite and the solvent was removed under vacuum and crude product was used directly in the next step.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08546404B2 |
|---|
| 出典データセット | uspto-grants-2013_10 |
|---|
| ORD ID | ord-0fa3a91681314b309e1665df91b7da55 |
|---|
| 出典メモ | uspto-grants-2013_10 |
|---|
