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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1038044Generated: October 30, 2026

Trifluoroacetic acid → 2-Piperidin-4-ylethynyl-pyrimidine

https://huagongshe.com/reaction/1038044

Reaction equation

Participants

RoleNameHCIDCharge
ReactantTrifluoroacetic acidHCID 6422—
Reactant4-Pyrimidin-2-ylethynyl-piperidine-1-carboxylic acid tert-butyl esterHCID 66939877—
Product2-Piperidin-4-ylethynyl-pyrimidineHCID 59511345—

Reaction Steps

4-Pyrimidin-2-ylethynyl-piperidine-1-carboxylic acid tert-butyl ester was treated with TFA for 10 minutes and concentrated, lyophilized to provide the title product.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08546404B2
Source datasetuspto-grants-2013_10
ORD IDord-8705dbee5eb34fe0831c59e65bca9734
Source noteuspto-grants-2013_10