4-(4-Bromophenyl)-4-hydroxypiperidine → 4-(4-Bromophenyl)-1,2,3,6-tetrahydropyridine

Participants

Reaction Conditions

Reaction Steps

4-(4-Bromophenyl)-4-piperidinol (68 g, 0.27 mol) was added in small portions to a solution of trifluoroacetic acid (205 ml) at r.t. and the mixture was heated at 90° C. for 2 hr. Solvents were then removed in vacuum to give 4-(4-bromophenyl)-1,2,3,6-tetrahydropyridine as pale yellow oil. The yellow oil was used in the next step without further purification.

Provenance & Evidence