HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Benzyl-3-dimethylaminomethyl-pyrrolidine-3-carboxylic acid methyl ester → 3-Dimethylaminomethyl-pyrrolidine-3-carboxylic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Benzyl-3-dimethylaminomethyl-pyrrolidine-3-carboxylic acid methyl ester | HCID 57686184 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 3-Dimethylaminomethyl-pyrrolidine-3-carboxylic acid methyl ester | HCID 57686113 | 96.5% |
Reaction Steps
A mixture of 1-benzyl-3-dimethylaminomethyl-pyrrolidine-3-carboxylic acid methyl ester (400 mg), 10% Pd/C (40 mg) and methanol (30 ml) was shaken in a hydrogen parr shaker at 45 psi for overnight. The mixture was filtered through celite, washed with ethyl acetate. The combined filtrate was concentrated to give the title compound as oil (260 mg, 96%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08546404B2 |
| Source dataset | uspto-grants-2013_10 |
| ORD ID | ord-8b850fa8657148eb99b90a7e8790a6c8 |
| Source note | uspto-grants-2013_10 |