Ammonium formate → HCID 86614438, compound

Participants

Reaction Steps

Added ammonium formate (100 mg, 1.58 mmol) to a suspension of 1-Benzyl-3-(1-hydroxy-ethyl)-pyrrolidine-3-carboxylic acid [3-(4-fluoro-phenyl)-1-trityl-indazol-5-yl]-amide (5N) (80 mg, 0.114 mmol) and 10% Pd/C (5 mg) in MeOH (5 ml) at room temperature then refluxed for 4 hours. The reaction was cooled, diluted with MeOH (20 ml) and filtered through a celite pad. The filtrate was concentrated and the residue dissolved in MeCl2 (40 ml), dried over MgSO4, filtered and solvent evaporated yielding 6N as a solid (60 mg, 87%) ESMS (MH, 611).

Provenance & Evidence