HCID 67419236, compound → HCID 86614440, compound

Participants

Reaction Steps

Added N—N-Diisopropylethylamine (0.3 ml, 1.72 mmol) to a mixture of 3-(1-Hydroxy-ethyl)-pyrrolidine-3-carboxylic acid [3-(4-fluoro-phenyl)-1Trityl-indazol-5-yl]-amide (6N) (600 mg, 0.98 mmol) and 2-Chloro-1-[2-methyl-4-(5-pyrimidin-2-yl-pyridin-2-yl)-piperazin-1-yl]-ethanone (360 mg, 1.15 mmol) in DMF (10 ml) at room temperature. The solvent was evaporated and the residue extracted with MeCl2 (100 ml) and H2O (50 ml). The organic layer was separated, washed with saturated NaCl solution (20 ml), dried over MgSO4, filtered and solvent evaporated yielding 9N as a solid (750 mg, 84%) ESMS (MH, 906).

Provenance & Evidence