Dimethyl Sulfoxide → HCID 86614441, compound

Participants

Reaction Conditions

Reaction Steps

Added DMSO (200 mg, 2.56 mmol) to a solution of oxalyl chloride (180 mg, 1.40 mmol) in MeCl2 (10 ml) at −78° C., then stirred at −78° C. for 1 hour. Added 3-(1-Hydroxy-ethyl)-1-{2-[2-methyl-4-(5-pyrimidin-2-yl-pyridin-2-yl)-piperazin-1-yl]-2-oxo-ethyl}-pyrrolidine-3-carboxylic acid [3-(4-fluoro-phenyl)-1Trityl-indazol-5-yl]-amide (9N) in MeCl2 (5 ml) at −78° C. then stirred at −78° C. for 2 hours. Triethylamine (200 mg, 1.96 mmol) was added, the solution allowed warm to room temperature then stirred overnight. Added water (50 ml) and MeCl2 (150 ml). The organic layer was separated, dried over MgSO4, filtered and solvent evaporated yielding 10N as a solid (600 mg, 66%) ESMS (MH, 904)

Provenance & Evidence