1,4-Dioxane hydrochloride → HCID 131730888, compound

HRID 1038086Notes

Reaction equation

HRID 1038086 reaction equation
[ClH:1].O1CCOCC1.C(OC([N:15]1[CH2:19][CH2:18][C:17]([NH2:39])([C:20](=[O:38])[NH:21][C:22]2[CH:23]=[C:24]3[C:28](=[CH:29][CH:30]=2)[NH:27][N:26]=[C:25]3[C:31]2[CH:36]=[CH:35][C:34]([F:37])=[CH:33][CH:32]=2)[CH2:16]1)=O)(C)(C)C>C(Cl)Cl>[ClH:1].[F:37][C:34]1[CH:35]=[CH:36][C:31]([C:25]2[C:24]3[C:28](=[CH:29][CH:30]=[C:22]([NH:21][C:20]([C:17]4([NH2:39])[CH2:18][CH2:19][NH:15][CH2:16]4)=[O:38])[CH:23]=3)[NH:27][N:26]=2)=[CH:32][CH:33]=1

Participants

4

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 67419256HCID 67419256, compound

Product 1

HCID 131730888HCID 131730888, compoundYield 69%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

4M HCl/dioxane (2 ml) was added to a solution of 3-Amino-3-[3-(4-fluoro-phenyl)-1H-indazol-5-ylcarbamoyl]-pyrrolidine-1-carboxylic acid tert-butyl ester (1P) (60 mg, 0.088 mmol) in MeCl2 (1 ml) at room temperature then stirred for 1 hour at room temperature. The solvent was evaporated. Hexanes (20 ml) was added and supernatant decanted. The residue was dried yielding title compound 2P as a white solid (20 mg, 69%). ESMS (MH 340).

Workup

  1. customThe solvent was evaporated
  2. additionHexanes (20 ml) was added
  3. customThe residue was dried

Sources & evidence

ORD record
ord-cd23d811fa5646d3b2c44190b037d81a
Source dataset
uspto-grants-2013_10
Patent number
US08546404B2

Reaction notes

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