HCID 57686201, compound → HCID 67419487, compound

HRID 1038090Notes

Reaction equation

HRID 1038090 reaction equation
FC1C=CC(C2C3C(=CC=C(NC(C4(NC=O)CCN(CC(=O)N5CCN(C6C=CC(C7N=CC=CN=7)=CC=6)CC5)C4)=O)C=3)NN=2)=CC=1.[F:49][C:50]1[CH:55]=[CH:54][C:53]([C:56]2[C:64]3[C:59](=[CH:60][CH:61]=[C:62]([NH:65][C:66]([C:68]4([NH:96]C=O)[CH2:72][CH2:71][N:70]([CH2:73][C:74]([N:76]5[CH2:81][CH2:80][N:79]([C:82]6[CH:87]=[CH:86][C:85]([C:88]7[N:93]=[CH:92][C:91]([CH3:94])=[CH:90][N:89]=7)=[CH:84][CH:83]=6)[CH2:78][CH:77]5[CH3:95])=[O:75])[CH2:69]4)=[O:67])[CH:63]=3)[NH:58][N:57]=2)=[CH:52][CH:51]=1>>[F:49][C:50]1[CH:51]=[CH:52][C:53]([C:56]2[C:64]3[C:59](=[CH:60][CH:61]=[C:62]([NH:65][C:66]([C:68]4([NH2:96])[CH2:72][CH2:71][N:70]([CH2:73][C:74]([N:76]5[CH2:81][CH2:80][N:79]([C:82]6[CH:87]=[CH:86][C:85]([C:88]7[N:89]=[CH:90][C:91]([CH3:94])=[CH:92][N:93]=7)=[CH:84][CH:83]=6)[CH2:78][CH:77]5[CH3:95])=[O:75])[CH2:69]4)=[O:67])[CH:63]=3)[NH:58][N:57]=2)=[CH:54][CH:55]=1

Participants

3

Reactant 2

HCID 57686201HCID 57686201, compoundHCID 86614445HCID 86614445, compound

Product 1

HCID 67419487HCID 67419487, compound

Procedure

Following essentially the same procedure as Example 361 except substituting compound 6P with an equivalent quantity of 8P, the title compound 11P was obtained as a mixture of 2 isomers. LCMS (MH 648) Retention time=2.90 minutes.

Sources & evidence

ORD record
ord-b7df71ef7ced484e8a57a33b22ae69f2
Source dataset
uspto-grants-2013_10
Patent number
US08546404B2

Reaction notes

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