Chloroacetyl chloride → 2-Chloro-1-(5-pyrimidin-2-yl-3',6'-dihydro-2'H-[2,4']bipyridinyl-1'-yl)-ethanone

Participants

Reaction Conditions

Reaction Steps

Added chloroacetyl chloride (0.35 g, 4.39 mmol) in MeCl2 (15 ml) to a solution of 5-Pyrimidin-2-yl-1′,2′,3′,6′-tetrahydro-[2,4′]bipyridinyl (3Q) (0.4 g, 1.68 mmol) and triethylamine (0.4 g, 2.87 mmol) in MeCl2 (10 ml) at 0° C., then stirred 2 hours at 0° C. Added saturated NaHCO3 solution and stirred an additional hour at 0° C. MeCl2 (100 ml) was added, organic layer separated, dried over Na2SO4, filtered and solvent evaporated yielding 4Q as a pale yellow solid (0.53 g, 100%) ESMS (MH 315).

Provenance & Evidence