HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trimethylsilyldiazomethane → 1-Tert-butyl 3-methyl 3-aminopyrrolidine-1,3-dicarboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trimethylsilyldiazomethane | HCID 167693 | — |
| Reactant | 1,3-Pyrrolidinedicarboxylic acid, 3-amino-, 1-(1,1-dimethylethyl) ester | HCID 86063120 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 1-Tert-butyl 3-methyl 3-aminopyrrolidine-1,3-dicarboxylate | HCID 57686281 | 98% |
Reaction Steps
Added (Trimethylsilyl)-diazomethane (2M in hexanes: 15 ml, 30 mmol) to a solution of 3-Amino pyrrolidine 1,3 dicarboxylic acid, 1-tert-butyl ester (900 mg, 3.9 mmol) in MeOH (5 ml) at room temperature. Stirred 10 minutes then evaporated solvent yielding 1T as an oil (0.9 g, 98%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08546404B2 |
| Source dataset | uspto-grants-2013_10 |
| ORD ID | ord-1fae8528d0ae4ed298eef3996e62bbe2 |
| Source note | uspto-grants-2013_10 |