HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,4-Dioxane hydrochloride → 3-(Formyl-methyl-amino)-pyrrolidine-3-carboxylic acid methyl ester, Hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,4-Dioxane hydrochloride | HCID 20443148 | — |
| Reactant | 1-(tert-butyl) 3-methyl 3-(N-methylformamido)pyrrolidine-1,3-dicarboxylate | HCID 57686234 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 3-(Formyl-methyl-amino)-pyrrolidine-3-carboxylic acid methyl ester, Hydrochloride | HCID 131730889 | 100% |
Reaction Steps
Added 4M HCl/dioxane (2 ml) to a solution of 3-(Formyl-methyl-amino)-pyrrolidine-1,3-dicarboxylic acid 1-tert-butyl ester 3-methyl ester (3T) (50 mg, 0.175 mmol) in MeCl2 (2 ml) at room temperature then stirred for 1 hour. The solvent was evaporated yielding 4T as a white solid (45 mg, 100%) ESMS (MH 187).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08546404B2 |
| Source dataset | uspto-grants-2013_10 |
| ORD ID | ord-374544aa041149cd8c70f2c53151b2ba |
| Source note | uspto-grants-2013_10 |