Hydrochloric Acid → HCID 86614446, compound

Participants

Reaction Steps

Added EDCl.HCl (75 mg, 0.39 mmol) and HOBT.H2O (50 mg, 0.37 mmol) to a solution of 3-(4-Fluoro-phenyl)-1trityl-indazol-5-ylamine (110 mg, 0.234 mmol) and 3-(Formyl-methyl-amino)-1-{2-oxo-2-[4-(4-pyrimidin-2-yl-phenyl)-3,6-dihydro-2H-pyridin-1-yl]-ethyl}-pyrrolidine-3-carboxylic acid, Lithium salt (6T) (95 mg, 0.211 mmol) in DMF (2 ml) and NMM (0.1 ml) at room temperature, then stirred overnight. The solvent was evaporated and residue extracted with MeCl2 (50 ml), washed with H2O (20 ml), dried over MgSO4, filtered and solvent evaporated yielding a residue which chromatographed on silica gel eluting with v/v 9:1 EtOAc:Hexanes yielding 7T as a white solid (89 mg, 44%) ESMS (MH 901).

Provenance & Evidence