Hydrochloric Acid → HCID 57686173, compound

Participants

Reaction Steps

Added 2M HCl (2 ml) to a solution of 3-(Formyl-methyl-amino)-1-{2-oxo-2-[4-(4-pyrimidin-2-yl-phenyl)-3,6-dihydro-2H-pyridin-1-yl]-ethyl}-pyrrolidine-3-carboxylic acid [3-(4-fluoro-phenyl)-1H-indazol-5-yl]-amide (8T) (11 mg, 0.017 mmol) in MeOH (5 ml) at room temperature for 4 days. Evaporated solvent Added H2O (20 ml), basified with 1N NaOH (2 ml), and extracted with MeCl2 (50 ml). Separated organic layer, dried over MgSO4, filtered and evaporated solvent, yielding residue which chromatographed on silica gel eluting with 10% MeCl2/MeOH yielding 9T (5 mg) ESMS (MH 631)

Provenance & Evidence