Ethylamine → ethyl-[4-(5-nitro-1-trityl-1H-indazol-3-yl)-pyridin-2-yl]-amine

Participants

Reaction Conditions

Reaction Steps

A mixture of 3-(2-fluoro-pyridin-4-yl)-5-nitro-1-trityl-1H-indazole (800 mg, 1.6 mmol) and 2M ethyl amine in THF (20 mL) was heated in a sealed tube at 80° C. for four days. Cooled to room temperature and concentrated. The crude product was purified by column chromatography on silica get eluting with a solution of ethyl acetate in hexane (1:1) to give the title compound (300 mg, 36%).

Provenance & Evidence