Cesium carbonate → HCID 76592932, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 2-bromo-5-iodopyrazine (200 mg, 0.704 mmol), cesium carbonate (400 mg, 1.23 mmol) and 2R methyl piperazine (85 mg, 0.85 mmol) in DMF (10 ml) was stirred at 100° C. overnight. The reaction was cooled and solvent evaporated. Water (100 ml) was added and insoluble solid was filtered, then dissolved in MeCl2 (100 ml), dried over Na2SO4, filtered and solvent evaporated yielding product (205 mg, 95%) Mass Spec (MH, 305)

Provenance & Evidence