Potassium Nitrate → 5-nitro-1H-indazole-3-carboxylic Acid

Participants

Reaction Steps

To a suspension of indazole-3-carboxylic acid 16AP (10.5 g, 64.8 mmol) in concentrated sulfuric acid (125 ml) at 0° C. was added KNO3 (64.8 mmol, 6.55 g). The reaction mixture was warmed up to r.t. After stirring for 4 hr at r.t, it was poured into a 525 ml of ice/water. Solid was collected by filtration and washed with water to give desired 5-nitro-1H-indazole-3-carboxylic acid 17AP (10.74 g, 80%).

Provenance & Evidence