HRID1038141

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：O=[N+]([O-])c1ccc2c(c1)c(-c1ccc(F)c(OCCO)c1)nn2C(c1ccccc1)(c1ccccc1)c1ccccc1

HCID68961452

未命名化合物

PRODUCTS

生成物

结构：Nc1ccc2c(c1)c(-c1ccc(F)c(OCCO)c1)nn2C(c1ccccc1)(c1ccccc1)c1ccccc1

HCID68530760

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

催化剂HCID23938

Palladium

溶剂HCID21867641

Toluene methanol

C8H12O

PROCEDURE

实验过程

A suspension of 3-[4-fluoro-3-(2-hydroxy-ethoxy)-phenyl]-1-trityl-5-nitro-1H-indazole 14AX (1.5 g) and catalytic amount of Pd on carbon (5 wt %, 300 mg) in 40 mL of methanol/toluene (1:1) was stirred under a hydrogen atmosphere for 1 d and filtered through Celite. The filtrate was concentrated to provide 3-[4-fluoro-3-(2-hydroxy-ethoxy)-phenyl]-1-trityl-1H-indazol-5-ylamine 15AX (1.4 g) as an off-white solid.

WORKUP

后处理

filtrationfiltered through Celite
concentrationThe filtrate was concentrated

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-b7bf2f684a9749849c22232992aaec69
来源数据集: uspto-grants-2013_10
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08546404B2
来源说明: uspto-grants-2013_10

反应 SMILES

[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:16]3[C:11](=[CH:12][CH:13]=[C:14]([N+:17]([O-])=O)[CH:15]=3)[N:10]([C:20]([C:33]3[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=3)([C:27]3[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=3)[C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=3)[N:9]=2)=[CH:4][C:3]=1[O:39][CH2:40][CH2:41][OH:42]>CO.C1(C)C=CC=CC=1.[Pd]>[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:16]3[C:11](=[CH:12][CH:13]=[C:14]([NH2:17])[CH:15]=3)[N:10]([C:20]([C:33]3[CH:34]=[CH:35][CH:36]=[CH:37][CH:38]=3)([C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=3)[C:27]3[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=3)[N:9]=2)=[CH:4][C:3]=1[O:39][CH2:40][CH2:41][OH:42]