Sodium Hydroxide → HCID 66674440, compound

HRID 1038263Notes

Reaction equation

HRID 1038263 reaction equation
C([O:3][C:4](=[O:18])[CH2:5][C:6]1[NH:15][C:14]2[C:9](=[N:10][CH:11]=[CH:12][CH:13]=2)[S:8](=[O:17])(=[O:16])[N:7]=1)C.[OH-].[Na+:20]>CO.O>[Na+:20].[O:17]=[S:8]1(=[O:16])[C:9]2[C:14](=[CH:13][CH:12]=[CH:11][N:10]=2)[NH:15][C:6]([CH2:5][C:4]([O-:18])=[O:3])=[N:7]1

Participants

5

Reactant 2

HCID 14798Sodium HydroxideHCID 59184502(1,1-Dioxo-1,4-dihydro-1lambda6-thia-2,4,8-triaza-naphthalen-3-yl)-acetic acid ethyl ester

Product 1

HCID 66674440HCID 66674440, compoundYield 100%

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent

Conditions

Temperature
25 °C

Procedure

(1,1-Dioxo-1,4-dihydro-1λ6-thia-2,4,8-triaza-naphthalen-3-yl)-acetic acid ethyl ester (0.25 g, 0.928 mmol) was dissolved in methanol (5 mL) at approximately 60° C. Sodium hydroxide (0.111 g, 2.79 mmol) was dissolved in water (2.5 mL). Upon cooling to 25° C., the solutions were combined. The mixture was stirred at 25° C. for 3 h. The mixture was stored at −40° C. for 16 h. The mixture was concentrated in vacuo to afford the crude product, (1,1-dioxo-1,4-dihydro-1λ6-thia-2,4,8-triaza-naphthalen-3-yl)-acetic acid sodium salt (˜0.928 mmol), as a yellow film, which was used in the next step without further purification.

Workup

  1. waitThe mixture was stored at −40° C. for 16 h
  2. concentrationThe mixture was concentrated in vacuo

Sources & evidence

ORD record
ord-c29465d180664f4aaa87eb38a3d8e62d
Source dataset
uspto-grants-2013_10
Patent number
US08546602B2

Reaction notes

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