Ethylene Glycol → HCID 86646403, compound

Participants

Reaction Steps

To a solution of N,N′-Diallyl-2,4,6-triiodo-5-isocyanatoisophthalamide in dichloromethane was added ethylene glycol (0.5 equivalent). The reaction mixture was stirred for 18 hours and then purified by column chromatography to give (3,5-Bis-diallylcarbamoyl-2,4,6-triiodo-phenyl)-carbamic acid 2-(3,5-bis-diallylcarbamoyl-2,4,6-triiodo-phenylcarbamoyloxy)-ethyl ester. A cis-dihydroxylation using OsO4 and NMMO was performed and the crude mixture was purified by preparative HPLC to give 1,3-bis-(N,N,N′,N′-tetrakis-(2,3-dihydroxypropyl))-2,4,6-triiodo-5-ureido-isophthalamide]-2-hydroxypropane as a white powder after freeze drying.

Provenance & Evidence