1,3-Propanediol → HCID 86646405, compound

Participants

Reaction Steps

To a solution of N,N′-Diallyl-2,4,6-triiodo-5-isocyanato-N,N′-dimethyl-isophthalamide in dichloromethane was added 1,3-propane diol (0.5 equivalent). The reaction mixture was stirred for 18 hours and then purified by column chromatography to give) [3,5-Bis-(allyl-methyl-carbamoyl)-2,4,6-triiodo-phenyl]-carbamic acid 3-[3,5-bis-(allyl-methyl-carbamoyl)-2,4,6-triiodo-phenyl]carbamoyloxy-propyl ester. A cis-dihydroxylation using OsO4 and NMMO was performed and the crude mixture was purified by preparative HPLC to give {3,5-Bis-[bis-(2,3-dihydroxy-propyl)-carbamoyl]-2,4,6-triiodo-phenyl}-carbamic acid 3-{3,5-Bis-[bis-(2,3-dihydroxy-propyl)-carbamoyl]-2,4,6-triiodo-phenylcarbamoyloxy}propyl ester as a white powder after freeze drying.

Provenance & Evidence