Methanol → HCID 57572488, compound

Participants

Reaction Steps

To a slurry of the trithiazolide 5 (27.1 g, 0.05 mol) in dichloromethane (600 mL), a mixture of 2 mL methylamine solution (40% wt in water, d=0.902) and isopropanol (30 mL) was added dropwise over 48 h. The reaction mixture was applied directly onto a gradient flash silica column (1-5% methanol in methylene chloride). The desired product was obtained as a thick, yellow oil, yield 7.5 g (71% based on the methylamine). 12.8 g of unreacted starting trithiazolide was recovered during the separation.

Provenance & Evidence