Methanol → HCID 57572489, compound

Participants

Reaction Steps

To slurry of the 2-methoxy-TIAM-trithiazolide 5 (27.1 g, 0.05 mol) and triethylamine (2 mL) in dichloromethane (600 mL), a solution of □-alanine ethyl ester HCl salt (1.1 g, 7 mmol) in DMF (15 mL) and dichloromethane (100 mL) was added dropwise over 36 h. The reaction mixture was applied directly onto a gradient flash silica column (1-3% methanol in dichloromethane). The desired product was obtained as thick, yellow oil. Yield 2.3 g (61% based on the □-alanine ethyl ester HCl salt).

Provenance & Evidence