反应详情

2-Benzyloxy-benzene-1,3,5-tricarboxylic acid tribenzyl ester (14) (52 g, 88 mmol) was hydrolyzed with NaOH (20 g, 0.5 mol) in 4:1 methanol-water (1 L). The solvents were removed under reduced pressure after the completion of hydrolysis, and the residue was dissolved in saline and extracted with recycling methylene chloride to remove the benzyl alcohol. 2-benzyloxy benzene-1,3,5-tricarboxylic acid (15) deposited after acidification of the solution. It was collected by filtration and dried under vacuum, yield 25.6 g, 92%.

1. customThe solvents were removed under reduced pressure
2. customafter the completion of hydrolysis
3. dissolutionthe residue was dissolved in saline
4. extractionextracted with recycling methylene chloride
5. customto remove the benzyl alcohol
6. filtrationIt was collected by filtration
7. customdried under vacuum, yield 25.6 g, 92%