Methanol → HCID 57572491, compound

Participants

Reaction Steps

To a solution of compound 18A (2.1 g, 3.65 mmol) in dichloromethane (100 mL), a solution of 0.1 mL methylamine solution (40% wt in water, d=0.902) and 50 mL dichloromethane was added dropwise over 24 h. The reaction progress was monitored by TLC chromatography. When the reaction was judged complete, the reaction mixture was directly applied to a gradient flash silica column (1-5% methanol in dicholoromethane). The desired product was obtained as yellow, thick oil; yield 1.22 g, (69% based on compound 18A).

Provenance & Evidence