Sodium Thiosulfate → Ubiquinol 10

Participants

Reaction Steps

30 g of ubiquinone (MW: 863.36) was dissolved in 300 ml of hexane. While the solution was stirred at room temperature, 300 ml of a 10% (w/v) sodium hyposulfite solution was poured to the solution. The mixture was stirred at room temperature for 2 hours. The mixture was all introduced into a separating funnel, and the hexane layer was collected. The remaining aqueous layer was then extracted twice each with 50 ml of hexane, and the extract was combined with the previously collected hexane layer. The hexane layer was washed six times each with 50 ml of a deaerated saturated saline solution, thereby obtaining a transparent hexane layer. After hexane was removed under a reduced pressure, nitrogen purging was performed for day and night, resulting in 29.5 g of a cream colored solid.

Provenance & Evidence