Bicarbonate Ion → 2-(4-Nitrophenyl)imidazo[2,1-b]benzothiazol-7-ol

HRID 1038311Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1038311
C(=O)([O-])[O-].C(=O)(O)[O-].C(=O)(O)[O-].[Na+].[NH2:14][C:15]1[S:16][C:17]2[CH:23]=[C:22]([OH:24])[CH:21]=[CH:20][C:18]=2[N:19]=1.[CH:25]1[C:30]([C:31]([CH2:33]Br)=O)=[CH:29][CH:28]=[C:27]([N+:35]([O-:37])=[O:36])[CH:26]=1>C(O)CCC.C(O)(C)C.C(O)C>[N+:35]([C:27]1[CH:28]=[CH:29][C:30]([C:31]2[N:14]=[C:15]3[N:19]([CH:33]=2)[C:18]2[CH:20]=[CH:21][C:22]([OH:24])=[CH:23][C:17]=2[S:16]3)=[CH:25][CH:26]=1)([O-:37])=[O:36]

Komponenten

9

Edukt 5

HCID 769Bicarbonate IonHCID 19660Carbonate IonHCID 334622-Amino-6-benzothiazololHCID 668402-Bromo-4'-nitroacetophenoneHCID 516892Sodium Bicarbonate

Produkt 1

HCID 299332572-(4-Nitrophenyl)imidazo[2,1-b]benzothiazol-7-ol

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 2631-ButanolLösungsmittelHCID 702EthanolLösungsmittelHCID 3776IsopropanolLösungsmittel

Reaktionsbedingungen

Temperatur
112.5 °C

Versuchsvorschrift

Alternatively, the reaction may be carried out in the presence of a base, for example, in the presence of one or more carbonate or bicarbonate salt. For example, sodium bicarbonate is added to a mixture of 2-amino-6-hydroxybenzothiazole and 2-bromo-4-nitroacetophenone in a suitable solvent such as ethanol, isopropanol or n-butanol, and the resulting mixture is stirred at a suitable temperature, for example, to reflux and maintained at reflux (110-115° C.) for 2-3 h or until the reaction is substantially complete.

Aufarbeitung

  1. customAlternatively, the reaction
  2. temperatureto reflux
  3. temperaturemaintained

Quellen und Nachweise

ORD-Eintrag
ord-0f8120178e0f487cad158d5a5ce7024f
Quelldatensatz
uspto-grants-2013_10
Patentnummer
US08551963B2

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