Triethylamine → (-)-Epibatidine-L-tartrate

HRID 1038343노트

반응식

HRID 1038343 반응식
[CH2:1]1[CH:6]2[NH:7][CH:3]([CH:4]([C:8]3[CH:13]=[CH:12][C:11]([Cl:14])=[N:10][CH:9]=3)[CH2:5]2)[CH2:2]1.Cl.Cl.C(N(CC)CC)C>ClCCl>[CH:13]1[C:8]([CH:4]2[CH:3]3[NH:7][CH:6]([CH2:1][CH2:2]3)[CH2:5]2)=[CH:9][N:10]=[C:11]([Cl:14])[CH:12]=1

참가 물질

4

반응물 2

HCID 8471TriethylamineHCID 21946437(+)-Epibatidine dihydrochloride

생성물 1

HCID 1204(-)-Epibatidine-L-tartrate

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

(+)-Epibatidine dihydrochloride was treated with triethyl amine (10 eq) in dichloromethane for 1 hour at room temperature and epibatidine was then isolated following standard isolation protocol.

출처 및 근거

ORD 기록
ord-3910a6e2e1414ff1a141f7e538b92e13
출처 데이터셋
uspto-grants-2013_10
특허 번호
US08551983B2

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