Hydrochloric Acid → HCID 25255743, compound

Participants

Reaction Conditions

Reaction Steps

250 mg ethyl 4-[4-[(2R)-3-[4-amino-3-chloro-5-(trifluoromethyl)phenyl]-1-oxo-2-[[[4-(1,2,4,5-tetrahydro-2-oxo-3H-1,3-benzodiazepin-3-yl)-1-piperidinyl]carbonyl]oxy]propyl]-1-piperazinyl]-piperidine-1-acetate (0.316 mmol) of are dissolved in 2.5 ml of tetrahydrofuran at ambient temperature. The solution is heated to 80° C. and combined with 98 μL isopropanolic hydrochloric acid (3.2 Mol/l, 0.316 mmol). The temperature is lowered by 5° C. every 30 minutes. The suspension formed is stirred for 12 hours at ambient temperature. The solid formed is filtered off, washed with a little tetrahydrofuran and dried for 12 hours at 35° C.

Provenance & Evidence